- Dipak Biswas
- Nanu S. Rathod
- K. S. Halagali
- R. B. Nidavani
- M. H. Shalavadi
- B. S. Biradar
- V. M. Chandrashekhar
- I. S. Muchchandi
- Amrendra Singh
- Praveen Khirwadkar
- Nishi Shukla
- Vikas Kumar Chaudhari
- R. Parthasarathy
- Amrender Singh
- K. P. Sampath Kumar
- Biswajit
- Chiranjib
- Pankaj
- K. K. Tripathi
- Margret Chandira
- M. R. Chandira
- Rishab Bhanot
- Darsh Gautam
- Parshuram Rai
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Bhowmik, Debjit
- Protective Effect of Punica granatum L. on Gentamicin-Induced Acute Renal Failure in Adult Rats
Authors
1 H.S.K College of Pharmacy, Bagalkot-587101, Karnataka, IN
2 HIPER, Hamirpur, Himachal Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 8, No 4 (2016), Pagination: 161-167Abstract
Aim: Study was undertaken to evaluate the effect of Punica granatum L.on Gentamicin-induced renal failure in rats.
Materials and methods: Gr.-I rats served as normal, received 0.5 ml of 5% Tween-80 in distilled water, Gr.-II was injected with Gentamicin (100 mg/kg, ip), Gr.-III was injected with Gentamicin and selenium (2 mg/kg, ip), and Gr.-IV-IX were given orally Punica granatum fruit chloroform extract (PGCE) and Punica granatum methanol extract (PGME) at the doses of 100, 200 and 400 mg/kg, respectively, were administered for eight days in Gentamicin-induced renal failure rats. On last day, Blood and 24 h urine was collected and used for estimation of serum and urine creatinine, urea, uric acid levels. The kidney homogenate was used for the estimation of LPO, SOD, CAT and GSH levels and Kidney sections were analyzed for histopathology.
Results: Gentamicin-induced (Gr.-II) had significant increase in levels of serum and urine creatinine, urea, uric acid, lipid peroxidation and significantly decrease in SOD, CAT and GSH levels as compared to normal (Gr.-I). The treatment of PGCE and PGME 100, 200 and 400 mg/kg doses (Gr. IV-IX), significantly decreases serum and urine creatinine, urea, uric acid and significantly increases SOD, CAT and GSH levels in kidney homogenate with significant decrease in lipid peroxidation as compared to Gr.-II.
Conclusions: The PGCE and PGME at the doses of 400 mg/kg, found to be more effective in protecting the Gentamicin-induced renal failure in rats.
Keywords
Gentamicin, Punica granatum, Renal Failure, Lipid Peroxidation, Antioxidant.
- Formulation and Evaluation of Methyl Phenidate Sustained Release Tablets
Authors
1 Himachal Institute of Pharmaceutical Education & Research (HIPER), Nadaun, H.P., IN
2 Institute of Pharmacy, Vikarm University, Ujjain, Madhya Pradesh, IN
3 Advance Institute of Biotech and Paramedical Sciences, Kanpur, IN
4 KHBS College of Pharmacy, Jaunpur, Uttar Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 199-206Abstract
Methyl phenidate is a medication that belongs to the drug class called central nervous system stimulants. Methylphenidate is prescribed for treating narcolepsy (uncontrollable sleepiness), and attention-deficit hyperactivity disorder (ADHD). The aim of the current investigation is to design oral twice a daily sustained release matrix tablets of methylphenidate 20mg, used for the treatment of narcolepsy and ADHD which can release the drug for 10 to 12 hours. The matrix tablets were prepared by the wet granulation method using varying concentrations of sustained release polymers HPMC, Eudragit and Ethyl cellulose. The compatibility of the drug with polymers and other excipients was ruled out by FT-IR studies and found to be compatible. The Methyl phenidate powder and the powder-blends of tablets were evaluated for their physical properties like angle of repose, bulk density and compressibility index and found to be good and satisfactory. The manufactured tablets were evaluated for in process and finished product quality control tests including appearance, dimensions, weight variation, hardness, friability, drug content uniformity, and in vitro drug release. The results of dissolution studies indicated all formulations released up to 12 hours and formulation containing ethyl cellulose (5%) i.e. F7 was the most successful formulation with 96.72% drug release at the end of 12 hours. Based on mathematical models the formulation F7 fitted into zero order and Korsmeyer-Peppas plot with 0.942 and 0.999 regression values respectively and show Fickian diffusion mechanism release.Keywords
Methyl Phenidate, Sustain Release Tablets, In-Vitro Dissolution Study.- In vitro Antioxidant Activity of Bark and Leaf of Thespesia populnea
Authors
1 Himachal Institute of Pharmacy Education and Research Naudan, Bela, Hamirpur, Himachal Pradesh-177033, IN
2 Himachal Institute of Pharmacy Education and Research, Naudan, Bela, Hamirpur, Himachal Pradesh-177033, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 8, No 1 (2016), Pagination: 1-4Abstract
The free radical scavenging activity of Thespesia populnea bark (TPBE) and leaves (TPLE) has been studied using the methanolic extracts. In vitro antioxidant potential of leaves and stem bark were evaluated in three different models viz superoxide radical scavenging activity, lipid peroxide radical scavenging activity and hydroxyl radical scavenging activity. The two methanolic extract were prepared with different concentration from a maximum of 400μg to minimum of 50μg. All extract have different level of antioxidant property. In comparison, the antioxidant scavenging activity in hydroxyl radical was higher, In super oxide radical was moderate and lesser in lipid peroxide radical. These observations confirm that methanolic extract of Thespesia populnea bark and leaf have different polyphenolic constituent and its importance in antioxidant activity.Keywords
Antioxidant, Thespesia populnea Leaf, Thespesia populnea Bark.- Pharmacognostical studies on Thespesia populnea Leaf
Authors
1 Himachal Institute of Pharmacy Education and Research, Naudan, Bela, Hamirpur, Himachal Pradesh -177033, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 8, No 1 (2016), Pagination: 16-20Abstract
Thespesia populnea is a reputed ever green tree belonging to the family Malvaceae; commonly known as Indian tulip tree. The plant is distributed tropical regions and coastal forest in India. It is well known and all the parts are used in traditional system of medicine. The plant has been used as astringent, antibacterial, hepatoprotective, haemostatic, anti-diarroheal and anti-inflammatory. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various pharmacognostical examinations like organoleptic or macroscopical characters, microscopical or anatomical studies, physical evaluation and preliminary phytochemical screening of various successive extracts were carried out and the parameters were reported. These studies indicated the possible information for correct identification and standardization of this plant material.Keywords
Thespesia populnea, Leaf Macroscopy, Leaf Microscopy.- Traditional Indian Herbal Plants Tulsi and Its Medicinal Importance
Authors
1 Department of Pharmaceutical Sciences, Coimbatore Medical College, Coimbatore, Tamilnadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 2 (2010), Pagination: 93-101Abstract
Tulsi has got the great medicinal value. Studies have also shown Tulsi to be effective for diabetes, by reducing blood glucose levels. The same study showed significant reduction in total cholesterol levels with Tulsi. Another study showed that Tulsi's beneficial effect on blood glucose levels is due to its antioxidant properties. The Rama Tulsi is the effective remedy for the severe acute Respiratory Syndrome. Juice of its leaves gives relief in cold, fever, bronchitis and cough. Tulsi oil is also used as the ear drop. Tulsi helps in curing malaria. It is very effective against indigestion, headache, hysteria, insomnia and cholera. The fresh leaves of Tulsi are taken by the millions of people every day. For over the centuries Tulsi (the queen of herbs) has been known for its remarkable healing properties. Modern scientific research offers impressive evidence that Tulsi reduces stress, enhances stamina, relieves inflammation, lowers cholesterol, eliminates toxins, protects against radiation, prevents gastric ulcers, lowers fevers, improves digestion and provides a rich supply of antioxidants and other nutrients. Tulsi is especially effective in supporting the heart, blood vessels, liver and lungs and also regulates blood pressure and blood sugar. Recent studies suggest that Tulsi may be a COX-2 inhibitor, like many modern painkillers, due to its high concentration of eugenol (1-hydroxy-2- methoxy-4-allylbenzene). Tulsi also shows some promise for protection from poisoning and cataracts. The oil extracted from the Karpoora Tulsi is mostly used in the herbal toiletry. Its oil is also used against the insects and bacteria. Tulsi can not only keep the dreaded Swine flu or H1N1 flu at bay but also help in fast recovery of an afflicted person, Ayurvedic practitioners claim. "The anti-flu property of Tulsi has been discovered by medical experts across the world quite recently. Tulsi improves the body's overall defence mechanism including its ability to fight viral diseases.- Zingiber officinale the Herbal and Traditional Medicine and Its Therapeutically Importance
Authors
1 Rajiv Gandhi College of Pharmacy Nautanwa, Maharajganj, Uttar Pradesh, IN
2 Department of Pharmaceutical Sciences, Coimbatore Medical Sciences, Coimbatore, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 2 (2010), Pagination: 102-110Abstract
Ginger is a perennial herb, with underground branching stems (rhizomes) which are swollen and tough. The leaves and rhizomes of ginger have a characteristic fragrance when cut or bruised. Rhizomes are dug out after the leafy parts are dried. Ginger, the underground stem, or rhizome, of the plant Zingiber officinale has been used as a medicine in Asian, Indian, and Arabic herbal traditions since ancient times. Ginger is considered an herbal remedy in many cultures. Over the years, it has been used to reduce inflammation, help with digestion, improve cardiovascular health and even historically to ward off diseases like the plague. The rhizome can be sliced, chopped, minced or served fresh but will always carry the trademark "heat" that has made it a medicinal mystery. Historically, people used ginger to fight disease and cure a fever since people would sweat when they would eat the ischolar_main. Although that helps, since it gets the metabolism racing and warms the body, we now realize that ginger offers additional medicinal benefits. Consumption of ginger helps with blood circulation and has antiinflammatory qualities that ease arthritis and other body aches and pains. It increases the body's production of saliva and other digestive fluids, which relieves an upset stomach and supports healthy digestion. Speeding up digestion helps clean the kidneys and bowels to remove toxins from the body. It also helps ease morning sickness, nausea and motion sickness. Ginger is said to improve digestion and has been known to pep up the appetite, promote saliva production, combat dyspepsia and relieve flatulent colic. It is also thought to be helpful for stomach cramps, alcoholic gastritis and hangover. The shogaol content in Ginger increases the activity of the digestive tract and is particularly helpful in digesting rich, fatty foods. Ginger has been used to cleanse the body of toxins through the skin by stimulating and increasing perspiration and has also been useful in breaking fevers. It is slightly diuretic and further cleanses the body by strengthening kidney function and increasing kidney filtration.
- Formulation and Evaluation of Telmisartan Fast Dissolving Tablets by Direct Compression Method
Authors
1 Himachal Institute of Pharmaceutical Education and Research, Nadaun, Hamirpur, H.P., IN
2 Department of Pharmacy, Coimbatore Government Medical College, Coimbatore, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 3 (2017), Pagination: 131-139Abstract
Telmisartan is a ACE inhibitor anti-hypertensive drug. Hence, in the present work, Telmisartan fast dissolving tablets will be prepared by using different super disintegrating agents. The amount of drug that is subject to first pass metabolism is reduced as compared to mouth dissolving tablets. Orally disintegration tablets contain wide variety of pharmaceutical active ingredients covering many therapeutic categories. The time for disintegration of orally disintegrating tablets are generally considered less than one minute. Orally disintegrating tablets are characterized by high porosity, low density and low hardness. The blend was examined for the precompressional parameters and post-compression parameters. Drug compatibility with excipients was checked by FTIR studies. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. In all the formulations, friability is less than 1%, indicated that tablets had a good mechanical resistance. Drug content was found to be in the range of 98 to 102%, which is within acceptable limits. Hardness of the tablets was found to be in the range of 3-4 Kp. The in vitro dispersion time was found to be in the range of 38-112sec with rapid in vitro dissolution within 3 min. No chemical interaction between drug and excipients was confirmed by FTIR studies. The drug release from tablets of Telmisartan prepared by direct compression showed that 98.20% drug release within 15 minutes.Keywords
Telmisartan, Fast Dissolving Tablets, Super Disintegrants.References
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